Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Identifieur interne : 001C60 ( Main/Exploration ); précédent : 001C59; suivant : 001C61Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Auteurs : Jonathon Torchia [Canada] ; Brian Golbourn [Canada] ; Shengrui Feng [Canada] ; King Ching Ho [Canada] ; Patrick Sin-Chan [Canada] ; Alexandre Vasiljevic [France] ; Joseph D. Norman [Canada] ; Paul Guilhamon [Canada] ; Livia Garzia [Canada] ; Natalia R. Agamez [Canada] ; Mei Lu [Canada] ; Tiffany S. Chan [Canada] ; Daniel Picard [Canada] ; Pasqualino De Antonellis [Canada] ; Dong-Anh Khuong-Quang [Canada] ; Aline C. Planello [Canada] ; Constanze Zeller [Canada] ; Dalia Barsyte-Lovejoy [Canada] ; Lucie Lafay-Cousin [Canada] ; Louis Letourneau [Canada] ; Mathieu Bourgey [Canada] ; Man Yu [Canada] ; Deena M. A. Gendoo [Canada] ; Misko Dzamba [Canada] ; Mark Barszczyk [Canada] ; Tiago Medina [Canada] ; Alexandra N. Riemenschneider [Canada] ; A. Sorana Morrissy [Canada] ; Young-Shin Ra [Corée du Sud] ; Vijay Ramaswamy [Canada] ; Marc Remke [Canada] ; Christopher P. Dunham [Canada] ; Stephen Yip [Canada] ; Ho-Keung Ng [République populaire de Chine] ; Jian-Qiang Lu [Canada] ; Vivek Mehta [Canada] ; Steffen Albrecht [Canada] ; Jose Pimentel [Portugal] ; Jennifer A. Chan [Canada] ; Gino R. Somers [Canada] ; Claudia C. Faria [Portugal] ; Lucia Roque [Portugal] ; Maryam Fouladi [États-Unis] ; Lindsey M. Hoffman [États-Unis] ; Andrew S. Moore [Australie] ; Yin Wang [République populaire de Chine] ; Seung Ah Choi [Corée du Sud] ; Jordan R. Hansford [Australie] ; Daniel Catchpoole [Australie] ; Diane K. Birks [États-Unis] ; Nicholas K. Foreman [États-Unis] ; Doug Strother [Canada] ; Almos Klekner [Hongrie] ; Laszl Bognár [Hongrie] ; Mikl S Garami [Hongrie] ; Péter Hauser [Hongrie] ; Tibor Hortobágyi [Hongrie] ; Beverly Wilson [Canada] ; Juliette Hukin [Canada] ; Anne-Sophie Carret [Canada] ; Timothy E. Van Meter [États-Unis] ; Eugene I. Hwang [États-Unis] ; Amar Gajjar [États-Unis] ; Shih-Hwa Chiou [Taïwan] ; Hideo Nakamura [Japon] ; Helen Toledano ; Iris Fried [Israël] ; Daniel Fults [États-Unis] ; Takafumi Wataya [Japon] ; Chris Fryer [Canada] ; David D. Eisenstat [Canada] ; Katrin Scheinemann [Canada] ; Adam J. Fleming [Canada] ; Donna L. Johnston [Canada] ; Jean Michaud [Canada] ; Shayna Zelcer [Canada] ; Robert Hammond [Canada] ; Samina Afzal [Canada] ; David A. Ramsay [Canada] ; Nongnuch Sirachainan [Thaïlande] ; Suradej Hongeng [Thaïlande] ; Noppadol Larbcharoensub [Thaïlande] ; Richard G. Grundy [Royaume-Uni] ; Rishi R. Lulla [États-Unis] ; Jason R. Fangusaro [États-Unis] ; Harriet Druker [Canada] ; Ute Bartels [Canada] ; Ronald Grant [Canada] ; David Malkin [Canada] ; C. Jane Mcglade [Canada] ; Theodore Nicolaides [États-Unis] ; Tarik Tihan [États-Unis] ; Joanna Phillips [États-Unis] ; Jacek Majewski [Canada] ; Alexandre Montpetit [Canada] ; Guillaume Bourque [Canada] ; Gary D. Bader [Canada] ; Alyssa T. Reddy [États-Unis] ; G. Yancey Gillespie [États-Unis] ; Monika Warmuth-Metz [Allemagne] ; Stefan Rutkowski [Allemagne] ; Uri Tabori [Canada] ; Mathieu Lupien [Canada] ; Michael Brudno [Canada] ; Ulrich Schüller [Allemagne] ; Torsten Pietsch [Allemagne] ; Alexander R. Judkins [États-Unis] ; Cynthia E. Hawkins [Canada] ; Eric Bouffet [Canada] ; Seung-Ki Kim [Corée du Sud] ; Peter B. Dirks [Canada] ; Michael D. Taylor [Canada] ; Anat Erdreich-Epstein [États-Unis] ; Cheryl H. Arrowsmith [Canada] ; Daniel D. De Carvalho [Canada] ; James T. Rutka [Canada] ; Nada Jabado [Canada] ; Annie Huang [Canada]Source :
- Cancer cell [ 1535-6108 ] ; 2016.
Descripteurs français
- KwdFr :
- Chromatine (génétique), Dasatinib (pharmacologie), Dasatinib (usage thérapeutique), Humains, Inhibiteurs de protéines kinases (pharmacologie), Inhibiteurs de protéines kinases (usage thérapeutique), Lignée cellulaire tumorale, Mutation, Méthylation de l'ADN, Prolifération cellulaire (), Protéine SMARCB1 (génétique), Pyrimidines (pharmacologie), Pyrimidines (usage thérapeutique), Récepteur au PDGF bêta (antagonistes et inhibiteurs), Récepteur au PDGF bêta (génétique), Survie cellulaire (), Tumeur rhabdoïde (génétique), Tumeur rhabdoïde (traitement médicamenteux), Tumeurs du système nerveux central (génétique), Tumeurs du système nerveux central (traitement médicamenteux), Tératome (génétique), Tératome (traitement médicamenteux), Épigenèse génétique (), Épigénomique ().
- MESH :
- antagonistes et inhibiteurs : Récepteur au PDGF bêta.
- génétique : Chromatine, Protéine SMARCB1, Récepteur au PDGF bêta, Tumeur rhabdoïde, Tumeurs du système nerveux central, Tératome.
- pharmacologie : Dasatinib, Inhibiteurs de protéines kinases, Pyrimidines.
- traitement médicamenteux : Tumeur rhabdoïde, Tumeurs du système nerveux central, Tératome.
- usage thérapeutique : Dasatinib, Inhibiteurs de protéines kinases, Pyrimidines.
- Humains, Lignée cellulaire tumorale, Mutation, Méthylation de l'ADN, Prolifération cellulaire, Survie cellulaire, Épigenèse génétique, Épigénomique.
English descriptors
- KwdEn :
- Cell Line, Tumor, Cell Proliferation (drug effects), Cell Survival (drug effects), Central Nervous System Neoplasms (drug therapy), Central Nervous System Neoplasms (genetics), Chromatin (genetics), DNA Methylation, Dasatinib (pharmacology), Dasatinib (therapeutic use), Epigenesis, Genetic (drug effects), Epigenomics (methods), Humans, Mutation, Protein Kinase Inhibitors (pharmacology), Protein Kinase Inhibitors (therapeutic use), Pyrimidines (pharmacology), Pyrimidines (therapeutic use), Receptor, Platelet-Derived Growth Factor beta (antagonists & inhibitors), Receptor, Platelet-Derived Growth Factor beta (genetics), Rhabdoid Tumor (drug therapy), Rhabdoid Tumor (genetics), SMARCB1 Protein (genetics), Teratoma (drug therapy), Teratoma (genetics).
- MESH :
- chemical , antagonists & inhibitors : Receptor, Platelet-Derived Growth Factor beta.
- chemical , genetics : Chromatin, Receptor, Platelet-Derived Growth Factor beta, SMARCB1 Protein.
- drug effects : Cell Proliferation, Cell Survival, Epigenesis, Genetic.
- drug therapy : Central Nervous System Neoplasms, Rhabdoid Tumor, Teratoma.
- genetics : Central Nervous System Neoplasms, Rhabdoid Tumor, Teratoma.
- methods : Epigenomics.
- chemical , pharmacology : Dasatinib, Protein Kinase Inhibitors, Pyrimidines.
- chemical , therapeutic use : Dasatinib, Protein Kinase Inhibitors, Pyrimidines.
- Cell Line, Tumor, DNA Methylation, Humans, Mutation.
Abstract
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
Url:
DOI: 10.1016/j.ccell.2016.11.003
PubMed: 27960086
PubMed Central: 5500911
Affiliations:
- Allemagne, Australie, Canada, Corée du Sud, France, Hongrie, Israël, Japon, Portugal, Royaume-Uni, République populaire de Chine, Taïwan, Thaïlande, États-Unis
- Alabama, Alberta, Angleterre, Bavière, Californie, Colorado, District de Basse-Franconie, District de Cologne, District de Columbia, Hambourg, Hongrie centrale, Illinois, Ohio, Ontario, Québec, Rhénanie-du-Nord-Westphalie, Région capitale de Séoul, Tennessee, Utah, Virginie
- Bonn, Budapest, Calgary, Hambourg, Hamilton (Ontario), Los Angeles, Montréal, Sha Tin, Séoul, Toronto, Wurtzbourg
- Université McGill, Université McMaster, Université chinoise de Hong Kong, Université de Calgary, Université de Californie du Sud, Université de Toronto
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Le document en format XML
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type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Sin Chan, Patrick" sort="Sin Chan, Patrick" uniqKey="Sin Chan P" first="Patrick" last="Sin-Chan">Patrick Sin-Chan</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Vasiljevic, Alexandre" sort="Vasiljevic, Alexandre" uniqKey="Vasiljevic A" first="Alexandre" last="Vasiljevic">Alexandre Vasiljevic</name><affiliation wicri:level="3"><nlm:aff id="A15">Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Norman, Joseph D" sort="Norman, Joseph D" uniqKey="Norman J" first="Joseph D." last="Norman">Joseph D. Norman</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Guilhamon, Paul" sort="Guilhamon, Paul" uniqKey="Guilhamon P" first="Paul" last="Guilhamon">Paul Guilhamon</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Picard, Daniel" sort="Picard, Daniel" uniqKey="Picard D" first="Daniel" last="Picard">Daniel Picard</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><affiliation wicri:level="4"><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Planello, Aline C" sort="Planello, Aline C" uniqKey="Planello A" first="Aline C." last="Planello">Aline C. Planello</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Zeller, Constanze" sort="Zeller, Constanze" uniqKey="Zeller C" first="Constanze" last="Zeller">Constanze Zeller</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Barsyte Lovejoy, Dalia" sort="Barsyte Lovejoy, Dalia" uniqKey="Barsyte Lovejoy D" first="Dalia" last="Barsyte-Lovejoy">Dalia Barsyte-Lovejoy</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Lafay Cousin, Lucie" sort="Lafay Cousin, Lucie" uniqKey="Lafay Cousin L" first="Lucie" last="Lafay-Cousin">Lucie Lafay-Cousin</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8</wicri:regionArea><wicri:noRegion>AB T3B6A8</wicri:noRegion></affiliation></author><author><name sortKey="Letourneau, Louis" sort="Letourneau, Louis" uniqKey="Letourneau L" first="Louis" last="Letourneau">Louis Letourneau</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bourgey, Mathieu" sort="Bourgey, Mathieu" uniqKey="Bourgey M" first="Mathieu" last="Bourgey">Mathieu Bourgey</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Dzamba, Misko" sort="Dzamba, Misko" uniqKey="Dzamba M" first="Misko" last="Dzamba">Misko Dzamba</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Barszczyk, Mark" sort="Barszczyk, Mark" uniqKey="Barszczyk M" first="Mark" last="Barszczyk">Mark Barszczyk</name><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Medina, Tiago" sort="Medina, Tiago" uniqKey="Medina T" first="Tiago" last="Medina">Tiago Medina</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Riemenschneider, Alexandra N" sort="Riemenschneider, Alexandra N" uniqKey="Riemenschneider A" first="Alexandra N." last="Riemenschneider">Alexandra N. Riemenschneider</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. Sorana Morrissy</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Ra, Young Shin" sort="Ra, Young Shin" uniqKey="Ra Y" first="Young-Shin" last="Ra">Young-Shin Ra</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Asan Medical Center, Seoul 138-736</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Dunham, Christopher P" sort="Dunham, Christopher P" uniqKey="Dunham C" first="Christopher P." last="Dunham">Christopher P. Dunham</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Yip, Stephen" sort="Yip, Stephen" uniqKey="Yip S" first="Stephen" last="Yip">Stephen Yip</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3</wicri:regionArea><wicri:noRegion>V6T1Z3</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation wicri:level="4"><nlm:aff id="A26">Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Jian Qiang" sort="Lu, Jian Qiang" uniqKey="Lu J" first="Jian-Qiang" last="Lu">Jian-Qiang Lu</name><affiliation wicri:level="1"><nlm:aff id="A27">Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Mehta, Vivek" sort="Mehta, Vivek" uniqKey="Mehta V" first="Vivek" last="Mehta">Vivek Mehta</name><affiliation wicri:level="1"><nlm:aff id="A28">Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><affiliation wicri:level="4"><nlm:aff id="A18">Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="Jose" last="Pimentel">Jose Pimentel</name><affiliation wicri:level="1"><nlm:aff id="A30">Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035</wicri:regionArea><wicri:noRegion>Lisbon 1649-035</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Jennifer A" sort="Chan, Jennifer A" uniqKey="Chan J" first="Jennifer A." last="Chan">Jennifer A. Chan</name><affiliation wicri:level="4"><nlm:aff id="A21">Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Somers, Gino R" sort="Somers, Gino R" uniqKey="Somers G" first="Gino R." last="Somers">Gino R. Somers</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Faria, Claudia C" sort="Faria, Claudia C" uniqKey="Faria C" first="Claudia C." last="Faria">Claudia C. Faria</name><affiliation wicri:level="1"><nlm:aff id="A31">Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035</wicri:regionArea><wicri:noRegion>Lisbon 1649-035</wicri:noRegion></affiliation></author><author><name sortKey="Roque, Lucia" sort="Roque, Lucia" uniqKey="Roque L" first="Lucia" last="Roque">Lucia Roque</name><affiliation wicri:level="1"><nlm:aff id="A32">Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023</wicri:regionArea><wicri:noRegion>Lisbon 1099-023</wicri:noRegion></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation wicri:level="2"><nlm:aff id="A33">Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M." last="Hoffman">Lindsey M. Hoffman</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name><affiliation wicri:level="1"><nlm:aff id="A35">Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102</wicri:regionArea><wicri:noRegion>QLD 4102</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yin" sort="Wang, Yin" uniqKey="Wang Y" first="Yin" last="Wang">Yin Wang</name><affiliation wicri:level="1"><nlm:aff id="A36">Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Institute of Health Development Strategies, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Seung Ah" sort="Choi, Seung Ah" uniqKey="Choi S" first="Seung Ah" last="Choi">Seung Ah Choi</name><affiliation wicri:level="1"><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R." last="Hansford">Jordan R. Hansford</name><affiliation wicri:level="1"><nlm:aff id="A38">Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Catchpoole, Daniel" sort="Catchpoole, Daniel" uniqKey="Catchpoole D" first="Daniel" last="Catchpoole">Daniel Catchpoole</name><affiliation wicri:level="1"><nlm:aff id="A39">Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145</wicri:regionArea><wicri:noRegion>NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Birks, Diane K" sort="Birks, Diane K" uniqKey="Birks D" first="Diane K." last="Birks">Diane K. Birks</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K." last="Foreman">Nicholas K. Foreman</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Strother, Doug" sort="Strother, Doug" uniqKey="Strother D" first="Doug" last="Strother">Doug Strother</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Klekner, Almos" sort="Klekner, Almos" uniqKey="Klekner A" first="Almos" last="Klekner">Almos Klekner</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurosurgery, University of Debrecen, Debrecen 4032</wicri:regionArea><wicri:noRegion>Debrecen 4032</wicri:noRegion></affiliation></author><author><name sortKey="Bognar, Laszl" sort="Bognar, Laszl" uniqKey="Bognar L" first="Laszl" last="Bognár">Laszl Bognár</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurosurgery, University of Debrecen, Debrecen 4032</wicri:regionArea><wicri:noRegion>Debrecen 4032</wicri:noRegion></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation wicri:level="1"><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest 1094</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hauser, Peter" sort="Hauser, Peter" uniqKey="Hauser P" first="Péter" last="Hauser">Péter Hauser</name><affiliation wicri:level="1"><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest 1094</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Histopathology, University of Szeged, Szeged 6720, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Histopathology, University of Szeged, Szeged 6720</wicri:regionArea><wicri:noRegion>Szeged 6720</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Carret, Anne Sophie" sort="Carret, Anne Sophie" uniqKey="Carret A" first="Anne-Sophie" last="Carret">Anne-Sophie Carret</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5</wicri:regionArea><wicri:noRegion>QC H3T1C5</wicri:noRegion></affiliation></author><author><name sortKey="Van Meter, Timothy E" sort="Van Meter, Timothy E" uniqKey="Van Meter T" first="Timothy E." last="Van Meter">Timothy E. Van Meter</name><affiliation wicri:level="2"><nlm:aff id="A44">Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Hwang, Eugene I" sort="Hwang, Eugene I" uniqKey="Hwang E" first="Eugene I." last="Hwang">Eugene I. Hwang</name><affiliation wicri:level="2"><nlm:aff id="A45">Department of Oncology, Children’s National Medical Center, Washington, DC 20010, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Children’s National Medical Center, Washington, DC 20010</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation wicri:level="2"><nlm:aff id="A46">Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chiou, Shih Hwa" sort="Chiou, Shih Hwa" uniqKey="Chiou S" first="Shih-Hwa" last="Chiou">Shih-Hwa Chiou</name><affiliation wicri:level="1"><nlm:aff id="A47">Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Hideo" sort="Nakamura, Hideo" uniqKey="Nakamura H" first="Hideo" last="Nakamura">Hideo Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556</wicri:regionArea><wicri:noRegion>Kumamoto 860-8556</wicri:noRegion></affiliation></author><author><name sortKey="Toledano, Helen" sort="Toledano, Helen" uniqKey="Toledano H" first="Helen" last="Toledano">Helen Toledano</name><affiliation><nlm:aff id="A49">Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Petach Tikva 49202, Isreal</nlm:aff><wicri:noCountry code="subfield">Isreal</wicri:noCountry></affiliation></author><author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Fults, Daniel" sort="Fults, Daniel" uniqKey="Fults D" first="Daniel" last="Fults">Daniel Fults</name><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Wataya, Takafumi" sort="Wataya, Takafumi" uniqKey="Wataya T" first="Takafumi" last="Wataya">Takafumi Wataya</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660</wicri:regionArea><wicri:noRegion>Shizuoka 420-8660</wicri:noRegion></affiliation></author><author><name sortKey="Fryer, Chris" sort="Fryer, Chris" uniqKey="Fryer C" first="Chris" last="Fryer">Chris Fryer</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Eisenstat, David D" sort="Eisenstat, David D" uniqKey="Eisenstat D" first="David D." last="Eisenstat">David D. Eisenstat</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Scheinemann, Katrin" sort="Scheinemann, Katrin" uniqKey="Scheinemann K" first="Katrin" last="Scheinemann">Katrin Scheinemann</name><affiliation wicri:level="4"><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Fleming, Adam J" sort="Fleming, Adam J" uniqKey="Fleming A" first="Adam J." last="Fleming">Adam J. Fleming</name><affiliation wicri:level="4"><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Johnston, Donna L" sort="Johnston, Donna L" uniqKey="Johnston D" first="Donna L." last="Johnston">Donna L. Johnston</name><affiliation wicri:level="1"><nlm:aff id="A54">Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1</wicri:regionArea><wicri:noRegion>ON K1H8L1</wicri:noRegion></affiliation></author><author><name sortKey="Michaud, Jean" sort="Michaud, Jean" uniqKey="Michaud J" first="Jean" last="Michaud">Jean Michaud</name><affiliation wicri:level="1"><nlm:aff id="A55">Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1</wicri:regionArea><wicri:noRegion>ON K1H8L1</wicri:noRegion></affiliation></author><author><name sortKey="Zelcer, Shayna" sort="Zelcer, Shayna" uniqKey="Zelcer S" first="Shayna" last="Zelcer">Shayna Zelcer</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5</wicri:regionArea><wicri:noRegion>ON N6A5A5</wicri:noRegion></affiliation></author><author><name sortKey="Hammond, Robert" sort="Hammond, Robert" uniqKey="Hammond R" first="Robert" last="Hammond">Robert Hammond</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9</wicri:regionArea><wicri:noRegion>ON N6A5W9</wicri:noRegion></affiliation></author><author><name sortKey="Afzal, Samina" sort="Afzal, Samina" uniqKey="Afzal S" first="Samina" last="Afzal">Samina Afzal</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2</wicri:regionArea><wicri:noRegion>NS B3H4R2</wicri:noRegion></affiliation></author><author><name sortKey="Ramsay, David A" sort="Ramsay, David A" uniqKey="Ramsay D" first="David A." last="Ramsay">David A. Ramsay</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9</wicri:regionArea><wicri:noRegion>ON N6A5W9</wicri:noRegion></affiliation></author><author><name sortKey="Sirachainan, Nongnuch" sort="Sirachainan, Nongnuch" uniqKey="Sirachainan N" first="Nongnuch" last="Sirachainan">Nongnuch Sirachainan</name><affiliation wicri:level="1"><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300</wicri:regionArea><wicri:noRegion>Bangkok 10300</wicri:noRegion></affiliation></author><author><name sortKey="Hongeng, Suradej" sort="Hongeng, Suradej" uniqKey="Hongeng S" first="Suradej" last="Hongeng">Suradej Hongeng</name><affiliation wicri:level="1"><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300</wicri:regionArea><wicri:noRegion>Bangkok 10300</wicri:noRegion></affiliation></author><author><name sortKey="Larbcharoensub, Noppadol" sort="Larbcharoensub, Noppadol" uniqKey="Larbcharoensub N" first="Noppadol" last="Larbcharoensub">Noppadol Larbcharoensub</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400</wicri:regionArea><wicri:noRegion>Bangkok 10400</wicri:noRegion></affiliation></author><author><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G." last="Grundy">Richard G. Grundy</name><affiliation wicri:level="2"><nlm:aff id="A61">Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD</wicri:cityArea></affiliation></author><author><name sortKey="Lulla, Rishi R" sort="Lulla, Rishi R" uniqKey="Lulla R" first="Rishi R." last="Lulla">Rishi R. Lulla</name><affiliation wicri:level="2"><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Fangusaro, Jason R" sort="Fangusaro, Jason R" uniqKey="Fangusaro J" first="Jason R." last="Fangusaro">Jason R. Fangusaro</name><affiliation wicri:level="2"><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Grant, Ronald" sort="Grant, Ronald" uniqKey="Grant R" first="Ronald" last="Grant">Ronald Grant</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Nicolaides, Theodore" sort="Nicolaides, Theodore" uniqKey="Nicolaides T" first="Theodore" last="Nicolaides">Theodore Nicolaides</name><affiliation wicri:level="2"><nlm:aff id="A63">Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tihan, Tarik" sort="Tihan, Tarik" uniqKey="Tihan T" first="Tarik" last="Tihan">Tarik Tihan</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Phillips, Joanna" sort="Phillips, Joanna" uniqKey="Phillips J" first="Joanna" last="Phillips">Joanna Phillips</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bader, Gary D" sort="Bader, Gary D" uniqKey="Bader G" first="Gary D." last="Bader">Gary D. Bader</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Reddy, Alyssa T" sort="Reddy, Alyssa T" uniqKey="Reddy A" first="Alyssa T." last="Reddy">Alyssa T. Reddy</name><affiliation wicri:level="2"><nlm:aff id="A65">Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Gillespie, G Yancey" sort="Gillespie, G Yancey" uniqKey="Gillespie G" first="G. Yancey" last="Gillespie">G. Yancey Gillespie</name><affiliation wicri:level="2"><nlm:aff id="A66">Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of Alabama, Birmingham, AL 35233</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Warmuth Metz, Monika" sort="Warmuth Metz, Monika" uniqKey="Warmuth Metz M" first="Monika" last="Warmuth-Metz">Monika Warmuth-Metz</name><affiliation wicri:level="3"><nlm:aff id="A67">Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University of Würzburg, Würzburg 97070</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name><affiliation wicri:level="1"><nlm:aff id="A70">Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105</wicri:regionArea><wicri:noRegion>53105</wicri:noRegion><placeName><settlement type="city">Bonn</settlement><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region></placeName></affiliation></author><author><name sortKey="Judkins, Alexander R" sort="Judkins, Alexander R" uniqKey="Judkins A" first="Alexander R." last="Judkins">Alexander R. Judkins</name><affiliation wicri:level="2"><nlm:aff id="A71">Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Ki" sort="Kim, Seung Ki" uniqKey="Kim S" first="Seung-Ki" last="Kim">Seung-Ki Kim</name><affiliation wicri:level="1"><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Erdreich Epstein, Anat" sort="Erdreich Epstein, Anat" uniqKey="Erdreich Epstein A" first="Anat" last="Erdreich-Epstein">Anat Erdreich-Epstein</name><affiliation wicri:level="4"><nlm:aff id="A72">Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Arrowsmith, Cheryl H" sort="Arrowsmith, Cheryl H" uniqKey="Arrowsmith C" first="Cheryl H." last="Arrowsmith">Cheryl H. Arrowsmith</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Rutka, James T" sort="Rutka, James T" uniqKey="Rutka J" first="James T." last="Rutka">James T. Rutka</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation wicri:level="4"><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27960086</idno><idno type="pmc">5500911</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911</idno><idno type="RBID">PMC:5500911</idno><idno type="doi">10.1016/j.ccell.2016.11.003</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001E04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E04</idno><idno type="wicri:Area/Pmc/Curation">001C60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C60</idno><idno type="wicri:Area/Pmc/Checkpoint">000835</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000835</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001486</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001486</idno><idno type="wicri:Area/PubMed/Curation">001464</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001464</idno><idno type="wicri:Area/PubMed/Checkpoint">001464</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001464</idno><idno type="wicri:Area/Ncbi/Merge">004022</idno><idno type="wicri:Area/Ncbi/Curation">004022</idno><idno type="wicri:Area/Ncbi/Checkpoint">004022</idno><idno type="wicri:doubleKey">1535-6108:2016:Torchia J:integrated:epi:genomic</idno><idno type="wicri:Area/Main/Merge">001C57</idno><idno type="wicri:Area/Main/Curation">001C60</idno><idno type="wicri:Area/Main/Exploration">001C60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors</title><author><name sortKey="Torchia, Jonathon" sort="Torchia, Jonathon" uniqKey="Torchia J" first="Jonathon" last="Torchia">Jonathon Torchia</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Shengrui" sort="Feng, Shengrui" uniqKey="Feng S" first="Shengrui" last="Feng">Shengrui Feng</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Sin Chan, Patrick" sort="Sin Chan, Patrick" uniqKey="Sin Chan P" first="Patrick" last="Sin-Chan">Patrick Sin-Chan</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Vasiljevic, Alexandre" sort="Vasiljevic, Alexandre" uniqKey="Vasiljevic A" first="Alexandre" last="Vasiljevic">Alexandre Vasiljevic</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677</wicri:regionArea><wicri:noRegion>69677</wicri:noRegion><wicri:noRegion>69677</wicri:noRegion></affiliation></author><author><name sortKey="Norman, Joseph D" sort="Norman, Joseph D" uniqKey="Norman J" first="Joseph D." last="Norman">Joseph D. Norman</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Guilhamon, Paul" sort="Guilhamon, Paul" uniqKey="Guilhamon P" first="Paul" last="Guilhamon">Paul Guilhamon</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Picard, Daniel" sort="Picard, Daniel" uniqKey="Picard D" first="Daniel" last="Picard">Daniel Picard</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><affiliation wicri:level="4"><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Planello, Aline C" sort="Planello, Aline C" uniqKey="Planello A" first="Aline C." last="Planello">Aline C. Planello</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Zeller, Constanze" sort="Zeller, Constanze" uniqKey="Zeller C" first="Constanze" last="Zeller">Constanze Zeller</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Barsyte Lovejoy, Dalia" sort="Barsyte Lovejoy, Dalia" uniqKey="Barsyte Lovejoy D" first="Dalia" last="Barsyte-Lovejoy">Dalia Barsyte-Lovejoy</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Lafay Cousin, Lucie" sort="Lafay Cousin, Lucie" uniqKey="Lafay Cousin L" first="Lucie" last="Lafay-Cousin">Lucie Lafay-Cousin</name><affiliation wicri:level="1"><nlm:aff id="A20">Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8</wicri:regionArea><wicri:noRegion>AB T3B6A8</wicri:noRegion></affiliation></author><author><name sortKey="Letourneau, Louis" sort="Letourneau, Louis" uniqKey="Letourneau L" first="Louis" last="Letourneau">Louis Letourneau</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bourgey, Mathieu" sort="Bourgey, Mathieu" uniqKey="Bourgey M" first="Mathieu" last="Bourgey">Mathieu Bourgey</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Dzamba, Misko" sort="Dzamba, Misko" uniqKey="Dzamba M" first="Misko" last="Dzamba">Misko Dzamba</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Barszczyk, Mark" sort="Barszczyk, Mark" uniqKey="Barszczyk M" first="Mark" last="Barszczyk">Mark Barszczyk</name><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Medina, Tiago" sort="Medina, Tiago" uniqKey="Medina T" first="Tiago" last="Medina">Tiago Medina</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Riemenschneider, Alexandra N" sort="Riemenschneider, Alexandra N" uniqKey="Riemenschneider A" first="Alexandra N." last="Riemenschneider">Alexandra N. Riemenschneider</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. Sorana Morrissy</name><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Ra, Young Shin" sort="Ra, Young Shin" uniqKey="Ra Y" first="Young-Shin" last="Ra">Young-Shin Ra</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurosurgery, Asan Medical Center, Seoul 138-736</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Dunham, Christopher P" sort="Dunham, Christopher P" uniqKey="Dunham C" first="Christopher P." last="Dunham">Christopher P. Dunham</name><affiliation wicri:level="1"><nlm:aff id="A23">Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Yip, Stephen" sort="Yip, Stephen" uniqKey="Yip S" first="Stephen" last="Yip">Stephen Yip</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3</wicri:regionArea><wicri:noRegion>V6T1Z3</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation wicri:level="4"><nlm:aff id="A26">Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Jian Qiang" sort="Lu, Jian Qiang" uniqKey="Lu J" first="Jian-Qiang" last="Lu">Jian-Qiang Lu</name><affiliation wicri:level="1"><nlm:aff id="A27">Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Mehta, Vivek" sort="Mehta, Vivek" uniqKey="Mehta V" first="Vivek" last="Mehta">Vivek Mehta</name><affiliation wicri:level="1"><nlm:aff id="A28">Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><affiliation wicri:level="4"><nlm:aff id="A18">Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="Jose" last="Pimentel">Jose Pimentel</name><affiliation wicri:level="1"><nlm:aff id="A30">Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035</wicri:regionArea><wicri:noRegion>Lisbon 1649-035</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Jennifer A" sort="Chan, Jennifer A" uniqKey="Chan J" first="Jennifer A." last="Chan">Jennifer A. Chan</name><affiliation wicri:level="4"><nlm:aff id="A21">Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Somers, Gino R" sort="Somers, Gino R" uniqKey="Somers G" first="Gino R." last="Somers">Gino R. Somers</name><affiliation wicri:level="1"><nlm:aff id="A12">Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Faria, Claudia C" sort="Faria, Claudia C" uniqKey="Faria C" first="Claudia C." last="Faria">Claudia C. Faria</name><affiliation wicri:level="1"><nlm:aff id="A31">Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035</wicri:regionArea><wicri:noRegion>Lisbon 1649-035</wicri:noRegion></affiliation></author><author><name sortKey="Roque, Lucia" sort="Roque, Lucia" uniqKey="Roque L" first="Lucia" last="Roque">Lucia Roque</name><affiliation wicri:level="1"><nlm:aff id="A32">Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal</nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023</wicri:regionArea><wicri:noRegion>Lisbon 1099-023</wicri:noRegion></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation wicri:level="2"><nlm:aff id="A33">Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M." last="Hoffman">Lindsey M. Hoffman</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name><affiliation wicri:level="1"><nlm:aff id="A35">Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102</wicri:regionArea><wicri:noRegion>QLD 4102</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yin" sort="Wang, Yin" uniqKey="Wang Y" first="Yin" last="Wang">Yin Wang</name><affiliation wicri:level="1"><nlm:aff id="A36">Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Institute of Health Development Strategies, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Seung Ah" sort="Choi, Seung Ah" uniqKey="Choi S" first="Seung Ah" last="Choi">Seung Ah Choi</name><affiliation wicri:level="1"><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R." last="Hansford">Jordan R. Hansford</name><affiliation wicri:level="1"><nlm:aff id="A38">Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Catchpoole, Daniel" sort="Catchpoole, Daniel" uniqKey="Catchpoole D" first="Daniel" last="Catchpoole">Daniel Catchpoole</name><affiliation wicri:level="1"><nlm:aff id="A39">Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145</wicri:regionArea><wicri:noRegion>NSW 2145</wicri:noRegion></affiliation></author><author><name sortKey="Birks, Diane K" sort="Birks, Diane K" uniqKey="Birks D" first="Diane K." last="Birks">Diane K. Birks</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K." last="Foreman">Nicholas K. Foreman</name><affiliation wicri:level="2"><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Colorado, Denver, CO 80045</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Strother, Doug" sort="Strother, Doug" uniqKey="Strother D" first="Doug" last="Strother">Doug Strother</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Klekner, Almos" sort="Klekner, Almos" uniqKey="Klekner A" first="Almos" last="Klekner">Almos Klekner</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurosurgery, University of Debrecen, Debrecen 4032</wicri:regionArea><wicri:noRegion>Debrecen 4032</wicri:noRegion></affiliation></author><author><name sortKey="Bognar, Laszl" sort="Bognar, Laszl" uniqKey="Bognar L" first="Laszl" last="Bognár">Laszl Bognár</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Neurosurgery, University of Debrecen, Debrecen 4032</wicri:regionArea><wicri:noRegion>Debrecen 4032</wicri:noRegion></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation wicri:level="1"><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest 1094</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hauser, Peter" sort="Hauser, Peter" uniqKey="Hauser P" first="Péter" last="Hauser">Péter Hauser</name><affiliation wicri:level="1"><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Second Department of Pediatrics, Semmelweis University, Budapest 1094</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation wicri:level="1"><nlm:aff id="A42">Department of Histopathology, University of Szeged, Szeged 6720, Hungary</nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Histopathology, University of Szeged, Szeged 6720</wicri:regionArea><wicri:noRegion>Szeged 6720</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Carret, Anne Sophie" sort="Carret, Anne Sophie" uniqKey="Carret A" first="Anne-Sophie" last="Carret">Anne-Sophie Carret</name><affiliation wicri:level="1"><nlm:aff id="A43">Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5</wicri:regionArea><wicri:noRegion>QC H3T1C5</wicri:noRegion></affiliation></author><author><name sortKey="Van Meter, Timothy E" sort="Van Meter, Timothy E" uniqKey="Van Meter T" first="Timothy E." last="Van Meter">Timothy E. Van Meter</name><affiliation wicri:level="2"><nlm:aff id="A44">Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Hwang, Eugene I" sort="Hwang, Eugene I" uniqKey="Hwang E" first="Eugene I." last="Hwang">Eugene I. Hwang</name><affiliation wicri:level="2"><nlm:aff id="A45">Department of Oncology, Children’s National Medical Center, Washington, DC 20010, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Children’s National Medical Center, Washington, DC 20010</wicri:regionArea><placeName><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation wicri:level="2"><nlm:aff id="A46">Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chiou, Shih Hwa" sort="Chiou, Shih Hwa" uniqKey="Chiou S" first="Shih-Hwa" last="Chiou">Shih-Hwa Chiou</name><affiliation wicri:level="1"><nlm:aff id="A47">Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112</wicri:regionArea><wicri:noRegion>Taipei 112</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Hideo" sort="Nakamura, Hideo" uniqKey="Nakamura H" first="Hideo" last="Nakamura">Hideo Nakamura</name><affiliation wicri:level="1"><nlm:aff id="A48">Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556</wicri:regionArea><wicri:noRegion>Kumamoto 860-8556</wicri:noRegion></affiliation></author><author><name sortKey="Toledano, Helen" sort="Toledano, Helen" uniqKey="Toledano H" first="Helen" last="Toledano">Helen Toledano</name><affiliation><nlm:aff id="A49">Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Petach Tikva 49202, Isreal</nlm:aff><wicri:noCountry code="subfield">Isreal</wicri:noCountry></affiliation></author><author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120</wicri:regionArea><wicri:noRegion>Jerusalem 91120</wicri:noRegion></affiliation></author><author><name sortKey="Fults, Daniel" sort="Fults, Daniel" uniqKey="Fults D" first="Daniel" last="Fults">Daniel Fults</name><affiliation wicri:level="2"><nlm:aff id="A51">Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Wataya, Takafumi" sort="Wataya, Takafumi" uniqKey="Wataya T" first="Takafumi" last="Wataya">Takafumi Wataya</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660</wicri:regionArea><wicri:noRegion>Shizuoka 420-8660</wicri:noRegion></affiliation></author><author><name sortKey="Fryer, Chris" sort="Fryer, Chris" uniqKey="Fryer C" first="Chris" last="Fryer">Chris Fryer</name><affiliation wicri:level="1"><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1</wicri:regionArea><wicri:noRegion>BC V6H3N1</wicri:noRegion></affiliation></author><author><name sortKey="Eisenstat, David D" sort="Eisenstat, David D" uniqKey="Eisenstat D" first="David D." last="Eisenstat">David D. Eisenstat</name><affiliation wicri:level="1"><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2</wicri:regionArea><wicri:noRegion>AB T2W3N2</wicri:noRegion></affiliation></author><author><name sortKey="Scheinemann, Katrin" sort="Scheinemann, Katrin" uniqKey="Scheinemann K" first="Katrin" last="Scheinemann">Katrin Scheinemann</name><affiliation wicri:level="4"><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Fleming, Adam J" sort="Fleming, Adam J" uniqKey="Fleming A" first="Adam J." last="Fleming">Adam J. Fleming</name><affiliation wicri:level="4"><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Johnston, Donna L" sort="Johnston, Donna L" uniqKey="Johnston D" first="Donna L." last="Johnston">Donna L. Johnston</name><affiliation wicri:level="1"><nlm:aff id="A54">Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1</wicri:regionArea><wicri:noRegion>ON K1H8L1</wicri:noRegion></affiliation></author><author><name sortKey="Michaud, Jean" sort="Michaud, Jean" uniqKey="Michaud J" first="Jean" last="Michaud">Jean Michaud</name><affiliation wicri:level="1"><nlm:aff id="A55">Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1</wicri:regionArea><wicri:noRegion>ON K1H8L1</wicri:noRegion></affiliation></author><author><name sortKey="Zelcer, Shayna" sort="Zelcer, Shayna" uniqKey="Zelcer S" first="Shayna" last="Zelcer">Shayna Zelcer</name><affiliation wicri:level="1"><nlm:aff id="A56">Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5</wicri:regionArea><wicri:noRegion>ON N6A5A5</wicri:noRegion></affiliation></author><author><name sortKey="Hammond, Robert" sort="Hammond, Robert" uniqKey="Hammond R" first="Robert" last="Hammond">Robert Hammond</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9</wicri:regionArea><wicri:noRegion>ON N6A5W9</wicri:noRegion></affiliation></author><author><name sortKey="Afzal, Samina" sort="Afzal, Samina" uniqKey="Afzal S" first="Samina" last="Afzal">Samina Afzal</name><affiliation wicri:level="1"><nlm:aff id="A58">Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2</wicri:regionArea><wicri:noRegion>NS B3H4R2</wicri:noRegion></affiliation></author><author><name sortKey="Ramsay, David A" sort="Ramsay, David A" uniqKey="Ramsay D" first="David A." last="Ramsay">David A. Ramsay</name><affiliation wicri:level="1"><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9</wicri:regionArea><wicri:noRegion>ON N6A5W9</wicri:noRegion></affiliation></author><author><name sortKey="Sirachainan, Nongnuch" sort="Sirachainan, Nongnuch" uniqKey="Sirachainan N" first="Nongnuch" last="Sirachainan">Nongnuch Sirachainan</name><affiliation wicri:level="1"><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300</wicri:regionArea><wicri:noRegion>Bangkok 10300</wicri:noRegion></affiliation></author><author><name sortKey="Hongeng, Suradej" sort="Hongeng, Suradej" uniqKey="Hongeng S" first="Suradej" last="Hongeng">Suradej Hongeng</name><affiliation wicri:level="1"><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300</wicri:regionArea><wicri:noRegion>Bangkok 10300</wicri:noRegion></affiliation></author><author><name sortKey="Larbcharoensub, Noppadol" sort="Larbcharoensub, Noppadol" uniqKey="Larbcharoensub N" first="Noppadol" last="Larbcharoensub">Noppadol Larbcharoensub</name><affiliation wicri:level="1"><nlm:aff id="A60">Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400</wicri:regionArea><wicri:noRegion>Bangkok 10400</wicri:noRegion></affiliation></author><author><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G." last="Grundy">Richard G. Grundy</name><affiliation wicri:level="2"><nlm:aff id="A61">Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD</wicri:cityArea></affiliation></author><author><name sortKey="Lulla, Rishi R" sort="Lulla, Rishi R" uniqKey="Lulla R" first="Rishi R." last="Lulla">Rishi R. Lulla</name><affiliation wicri:level="2"><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Fangusaro, Jason R" sort="Fangusaro, Jason R" uniqKey="Fangusaro J" first="Jason R." last="Fangusaro">Jason R. Fangusaro</name><affiliation wicri:level="2"><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Grant, Ronald" sort="Grant, Ronald" uniqKey="Grant R" first="Ronald" last="Grant">Ronald Grant</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Nicolaides, Theodore" sort="Nicolaides, Theodore" uniqKey="Nicolaides T" first="Theodore" last="Nicolaides">Theodore Nicolaides</name><affiliation wicri:level="2"><nlm:aff id="A63">Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tihan, Tarik" sort="Tihan, Tarik" uniqKey="Tihan T" first="Tarik" last="Tihan">Tarik Tihan</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Phillips, Joanna" sort="Phillips, Joanna" uniqKey="Phillips J" first="Joanna" last="Phillips">Joanna Phillips</name><affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Bader, Gary D" sort="Bader, Gary D" uniqKey="Bader G" first="Gary D." last="Bader">Gary D. Bader</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Reddy, Alyssa T" sort="Reddy, Alyssa T" uniqKey="Reddy A" first="Alyssa T." last="Reddy">Alyssa T. Reddy</name><affiliation wicri:level="2"><nlm:aff id="A65">Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Gillespie, G Yancey" sort="Gillespie, G Yancey" uniqKey="Gillespie G" first="G. Yancey" last="Gillespie">G. Yancey Gillespie</name><affiliation wicri:level="2"><nlm:aff id="A66">Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, University of Alabama, Birmingham, AL 35233</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Warmuth Metz, Monika" sort="Warmuth Metz, Monika" uniqKey="Warmuth Metz M" first="Monika" last="Warmuth-Metz">Monika Warmuth-Metz</name><affiliation wicri:level="3"><nlm:aff id="A67">Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuroradiology, University of Würzburg, Würzburg 97070</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name><affiliation wicri:level="1"><nlm:aff id="A68">Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Computer Science, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name><affiliation wicri:level="1"><nlm:aff id="A69">Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246</wicri:regionArea><wicri:noRegion>20246</wicri:noRegion><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name><affiliation wicri:level="1"><nlm:aff id="A70">Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105</wicri:regionArea><wicri:noRegion>53105</wicri:noRegion><placeName><settlement type="city">Bonn</settlement><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region></placeName></affiliation></author><author><name sortKey="Judkins, Alexander R" sort="Judkins, Alexander R" uniqKey="Judkins A" first="Alexander R." last="Judkins">Alexander R. Judkins</name><affiliation wicri:level="2"><nlm:aff id="A71">Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Ki" sort="Kim, Seung Ki" uniqKey="Kim S" first="Seung-Ki" last="Kim">Seung-Ki Kim</name><affiliation wicri:level="1"><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Erdreich Epstein, Anat" sort="Erdreich Epstein, Anat" uniqKey="Erdreich Epstein A" first="Anat" last="Erdreich-Epstein">Anat Erdreich-Epstein</name><affiliation wicri:level="4"><nlm:aff id="A72">Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Arrowsmith, Cheryl H" sort="Arrowsmith, Cheryl H" uniqKey="Arrowsmith C" first="Cheryl H." last="Arrowsmith">Cheryl H. Arrowsmith</name><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><affiliation wicri:level="4"><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7</wicri:regionArea><wicri:noRegion>ON M5G1L7</wicri:noRegion></affiliation></author><author><name sortKey="Rutka, James T" sort="Rutka, James T" uniqKey="Rutka J" first="James T." last="Rutka">James T. Rutka</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Surgery, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation wicri:level="4"><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8</wicri:regionArea><wicri:noRegion>ON M5G1X8</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="ISSN">1535-6108</idno><idno type="eISSN">1878-3686</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line, Tumor</term><term>Cell Proliferation (drug effects)</term><term>Cell Survival (drug effects)</term><term>Central Nervous System Neoplasms (drug therapy)</term><term>Central Nervous System Neoplasms (genetics)</term><term>Chromatin (genetics)</term><term>DNA Methylation</term><term>Dasatinib (pharmacology)</term><term>Dasatinib (therapeutic use)</term><term>Epigenesis, Genetic (drug effects)</term><term>Epigenomics (methods)</term><term>Humans</term><term>Mutation</term><term>Protein Kinase Inhibitors (pharmacology)</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Pyrimidines (pharmacology)</term><term>Pyrimidines (therapeutic use)</term><term>Receptor, Platelet-Derived Growth Factor beta (antagonists & inhibitors)</term><term>Receptor, Platelet-Derived Growth Factor beta (genetics)</term><term>Rhabdoid Tumor (drug therapy)</term><term>Rhabdoid Tumor (genetics)</term><term>SMARCB1 Protein (genetics)</term><term>Teratoma (drug therapy)</term><term>Teratoma (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chromatine (génétique)</term><term>Dasatinib (pharmacologie)</term><term>Dasatinib (usage thérapeutique)</term><term>Humains</term><term>Inhibiteurs de protéines kinases (pharmacologie)</term><term>Inhibiteurs de protéines kinases (usage thérapeutique)</term><term>Lignée cellulaire tumorale</term><term>Mutation</term><term>Méthylation de l'ADN</term><term>Prolifération cellulaire ()</term><term>Protéine SMARCB1 (génétique)</term><term>Pyrimidines (pharmacologie)</term><term>Pyrimidines (usage thérapeutique)</term><term>Récepteur au PDGF bêta (antagonistes et inhibiteurs)</term><term>Récepteur au PDGF bêta (génétique)</term><term>Survie cellulaire ()</term><term>Tumeur rhabdoïde (génétique)</term><term>Tumeur rhabdoïde (traitement médicamenteux)</term><term>Tumeurs du système nerveux central (génétique)</term><term>Tumeurs du système nerveux central (traitement médicamenteux)</term><term>Tératome (génétique)</term><term>Tératome (traitement médicamenteux)</term><term>Épigenèse génétique ()</term><term>Épigénomique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Receptor, Platelet-Derived Growth Factor beta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chromatin</term><term>Receptor, Platelet-Derived Growth Factor beta</term><term>SMARCB1 Protein</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Récepteur au PDGF bêta</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Cell Survival</term><term>Epigenesis, Genetic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Central Nervous System Neoplasms</term><term>Rhabdoid Tumor</term><term>Teratoma</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Central Nervous System Neoplasms</term><term>Rhabdoid Tumor</term><term>Teratoma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromatine</term><term>Protéine SMARCB1</term><term>Récepteur au PDGF bêta</term><term>Tumeur rhabdoïde</term><term>Tumeurs du système nerveux central</term><term>Tératome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Epigenomics</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Dasatinib</term><term>Inhibiteurs de protéines kinases</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dasatinib</term><term>Protein Kinase Inhibitors</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dasatinib</term><term>Protein Kinase Inhibitors</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeur rhabdoïde</term><term>Tumeurs du système nerveux central</term><term>Tératome</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dasatinib</term><term>Inhibiteurs de protéines kinases</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>DNA Methylation</term><term>Humans</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Mutation</term><term>Méthylation de l'ADN</term><term>Prolifération cellulaire</term><term>Survie cellulaire</term><term>Épigenèse génétique</term><term>Épigénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P1">We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Hongrie</li><li>Israël</li><li>Japon</li><li>Portugal</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Taïwan</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Alabama</li><li>Alberta</li><li>Angleterre</li><li>Bavière</li><li>Californie</li><li>Colorado</li><li>District de Basse-Franconie</li><li>District de Cologne</li><li>District de Columbia</li><li>Hambourg</li><li>Hongrie centrale</li><li>Illinois</li><li>Ohio</li><li>Ontario</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région capitale de Séoul</li><li>Tennessee</li><li>Utah</li><li>Virginie</li></region><settlement><li>Bonn</li><li>Budapest</li><li>Calgary</li><li>Hambourg</li><li>Hamilton (Ontario)</li><li>Los Angeles</li><li>Montréal</li><li>Sha Tin</li><li>Séoul</li><li>Toronto</li><li>Wurtzbourg</li></settlement><orgName><li>Université McGill</li><li>Université McMaster</li><li>Université chinoise de Hong Kong</li><li>Université de Calgary</li><li>Université de Californie du Sud</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Toledano, Helen" sort="Toledano, Helen" uniqKey="Toledano H" first="Helen" last="Toledano">Helen Toledano</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Torchia, Jonathon" sort="Torchia, Jonathon" uniqKey="Torchia J" first="Jonathon" last="Torchia">Jonathon Torchia</name></region><name sortKey="Afzal, Samina" sort="Afzal, Samina" uniqKey="Afzal S" first="Samina" last="Afzal">Samina Afzal</name><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><name sortKey="Arrowsmith, Cheryl H" sort="Arrowsmith, Cheryl H" uniqKey="Arrowsmith C" first="Cheryl H." last="Arrowsmith">Cheryl H. Arrowsmith</name><name sortKey="Bader, Gary D" sort="Bader, Gary D" uniqKey="Bader G" first="Gary D." last="Bader">Gary D. Bader</name><name sortKey="Barsyte Lovejoy, Dalia" sort="Barsyte Lovejoy, Dalia" uniqKey="Barsyte Lovejoy D" first="Dalia" last="Barsyte-Lovejoy">Dalia Barsyte-Lovejoy</name><name sortKey="Barszczyk, Mark" sort="Barszczyk, Mark" uniqKey="Barszczyk M" first="Mark" last="Barszczyk">Mark Barszczyk</name><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><name sortKey="Bourgey, Mathieu" sort="Bourgey, Mathieu" uniqKey="Bourgey M" first="Mathieu" last="Bourgey">Mathieu Bourgey</name><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><name sortKey="Carret, Anne Sophie" sort="Carret, Anne Sophie" uniqKey="Carret A" first="Anne-Sophie" last="Carret">Anne-Sophie Carret</name><name sortKey="Chan, Jennifer A" sort="Chan, Jennifer A" uniqKey="Chan J" first="Jennifer A." last="Chan">Jennifer A. Chan</name><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><name sortKey="Dunham, Christopher P" sort="Dunham, Christopher P" uniqKey="Dunham C" first="Christopher P." last="Dunham">Christopher P. Dunham</name><name sortKey="Dzamba, Misko" sort="Dzamba, Misko" uniqKey="Dzamba M" first="Misko" last="Dzamba">Misko Dzamba</name><name sortKey="Eisenstat, David D" sort="Eisenstat, David D" uniqKey="Eisenstat D" first="David D." last="Eisenstat">David D. Eisenstat</name><name sortKey="Feng, Shengrui" sort="Feng, Shengrui" uniqKey="Feng S" first="Shengrui" last="Feng">Shengrui Feng</name><name sortKey="Feng, Shengrui" sort="Feng, Shengrui" uniqKey="Feng S" first="Shengrui" last="Feng">Shengrui Feng</name><name sortKey="Fleming, Adam J" sort="Fleming, Adam J" uniqKey="Fleming A" first="Adam J." last="Fleming">Adam J. Fleming</name><name sortKey="Fryer, Chris" sort="Fryer, Chris" uniqKey="Fryer C" first="Chris" last="Fryer">Chris Fryer</name><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><name sortKey="Grant, Ronald" sort="Grant, Ronald" uniqKey="Grant R" first="Ronald" last="Grant">Ronald Grant</name><name sortKey="Guilhamon, Paul" sort="Guilhamon, Paul" uniqKey="Guilhamon P" first="Paul" last="Guilhamon">Paul Guilhamon</name><name sortKey="Hammond, Robert" sort="Hammond, Robert" uniqKey="Hammond R" first="Robert" last="Hammond">Robert Hammond</name><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><name sortKey="Johnston, Donna L" sort="Johnston, Donna L" uniqKey="Johnston D" first="Donna L." last="Johnston">Donna L. Johnston</name><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><name sortKey="Lafay Cousin, Lucie" sort="Lafay Cousin, Lucie" uniqKey="Lafay Cousin L" first="Lucie" last="Lafay-Cousin">Lucie Lafay-Cousin</name><name sortKey="Letourneau, Louis" sort="Letourneau, Louis" uniqKey="Letourneau L" first="Louis" last="Letourneau">Louis Letourneau</name><name sortKey="Lu, Jian Qiang" sort="Lu, Jian Qiang" uniqKey="Lu J" first="Jian-Qiang" last="Lu">Jian-Qiang Lu</name><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><name sortKey="Medina, Tiago" sort="Medina, Tiago" uniqKey="Medina T" first="Tiago" last="Medina">Tiago Medina</name><name sortKey="Mehta, Vivek" sort="Mehta, Vivek" uniqKey="Mehta V" first="Vivek" last="Mehta">Vivek Mehta</name><name sortKey="Michaud, Jean" sort="Michaud, Jean" uniqKey="Michaud J" first="Jean" last="Michaud">Jean Michaud</name><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. Sorana Morrissy</name><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. 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Grundy</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Warmuth Metz, Monika" sort="Warmuth Metz, Monika" uniqKey="Warmuth Metz M" first="Monika" last="Warmuth-Metz">Monika Warmuth-Metz</name></region><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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